Mental patients lack more than ordinary people. Can vitamin D be cured of mental illness? Latest research

Vitamin D deficiency is more common among psychiatric patients than in the general population, and animal experiments have also found that lower vitamin D is related to brain changes, so some experts believe that vitamin D may have neuroprotective effects, and supplementing vitamin D may improve psychosis.

In order to prove this hypothesis, two random, double-blind, and consolation-controlled clinical trials have been published in medical journals.

The first article was Vitamin D Supplementation in Chronic Schizophrenia Patients Treated with Clozapine: A Randomized, Double-Blind, Placebo-controlled Clinical Trial (Vitamin D supplement for patients with chronic schizophrenia: a random, double-blind, consolation-controlled clinical trial). During this trial, psychiatric patients took 14,000 IU of vitamin D supplements per week for 8 consecutive weeks, and the results showed no benefit compared to the comfort agent.

The second article is the Effect of Vitamin D Supplementation on Outcomes in People With Early Psychosis published the day before yesterday (2021-12-28).

This multicenter, double-blind, consolation-controlled, parallel-group random clinical trials in the UK conducted examinations of adults aged 18 to 65 within 3 years of first functional psychosis. At the beginning of the trial, a total of 2136 patients were evaluated for qualifications, and then after passing the level of screening, only 149 patients were confirmed to be eligible. Their average age is 28.1 years old, of which 89 are male, 60 are female, 84 are white, and 65 are black or other minority groups. A total of 106 (74.6%) of these patients had a vitamin D concentration below 20 ng/mL, while 58 of them were even less than 10 ng/mL.

These patients were randomly evenly distributed into two groups, with the experiment group taking 120,000 IU of vitamin D oral solution once a month for 6 consecutive months, and the control group taking placement agents (triglycerides). Oral administration is performed by researchers to patients.

The results were:

1. The vitamin D concentration in the experimental group increased significantly (mean 16 ng/mL)

2. At 6 months, there was no difference between the intention-to-treat analysis of the main conclusions

3. At 3 months and 6 months, no difference was observed in the secondary results analysis

4. The overall evaluation of Function symptom score

5. Function disability There is no significant difference in overall score rating

6. Calgary Depression Scale score

So, the summary of this article is that no correlation between vitamin supplement D and 6-month mental health or 6-month results was found in this random clinical trial.

Original text: Vitamin D Treats mental illness? Latest research